RAF Typhoon FGR4s have operated alongside French aircraft in a coordinated attack on an underground arms cache in Syria used by the Islamic State group (IS), as stated by the UK's MoD.
The location, located using reconnaissance, was believed to be housing weapons and explosive materials, the statement said, and was situated in mountainous terrain just above the ancient city of Palmyra in Syria's central region.
"The RAF jets employed laser-guided Paveway IV weapons to hit a several approach shafts down to the depot... early reports indicate the strike was effective," officials stated.
There was no indication of any civilian impact in the strike on Saturday evening and every plane involved returned safely, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager refuelling tanker.
Daesh - also known as ISIS - established extremist governance over significant areas in Syria and Iraq prior to its 2019 collapse.
"This operation demonstrates our UK leadership, and resolve to stand shoulder to shoulder with allied nations, to stamp out any resurgence of the terrorist group and their violent and radical beliefs in the Middle East," Britain's Defence Chief the Defence Secretary stated.
RAF aircraft have performed surveillance missions over Syria to "prevent any efforts to regroup" of Islamic State subsequent to its defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank the personnel of the UK armed forces involved in this mission for their expertise and their valour," the Defence Secretary commented. "They were part of thousands of British troops deployed over the festive period. This operation, to take out dangerous terrorists who pose a risk to our security, shows how British military are ready to step up, throughout the year, ensuring Britain's security within its borders and powerful internationally."
In December, the US military carried out what it called a "large-scale strike" targeting Islamic State objectives in the country, subsequent to an attack resulted in the deaths of two US servicemembers and a civilian linguist in Palmyra.
The United Nations estimates Islamic State still boasts an estimated 5,000 to 7,000 militants in Iraq and Syria.